Marine Natural Products in Drug Discovery (formal seminar)

  1. Introduction
  • Marine natural products drug discovery has gone through a great reawakening over the past few years.
  • The large-scale discovery, screening and collection of novel marine natural products has led to the introduction of new chemical entities into the clinic for the treatment of diseases such as cancer, pain among other diseases.
  • Approval has been made for the first two drugs (for the treatment of cancer and chronic pain) that have been discovered from marine organisms.

  • More drugs such as eribulin mesylate and anticancer compounds are yet to be approved.
  • Over the past few years, researchers have expressed an increased appetite for marine natural products as a source of drugs to treat different diseases and disorders (John 2). As a result, there is a wide array of medicines shelved in the pharmaceutical stores which traces their origin in plants and organism in aquatic settings.
  • There are several illnesses which have been addressed by the drugs’ experts using marine natural products including cancer and hormonal imbalances. That success has been down to the dynamism in technological growth in the field of science and the general public preference towards natural products.
  • Through technological advances, the isolation, identification, and categorization of different compounds and medicinal elements of natural products have been alleviated.
  • The trend in marine natural products drug discovery has shown prospects of leading to better and productive results. It is therefore essential to evaluate the progress of the experts in the field. To that end, this presentation outlines the developments achieved in the pharmaceutical world using marine natural products.

  1. Experimental Methods and Design
  • The primary method of data collection used herein is the qualitative analysis of secondary materials – mainly from the ACS database. After gathering information from the journal articles, which are specific in scope, the data will then be integrated to formulate a conclusive statement regarding the use of marine natural products used in the drugs’ industry.
  • The use of scholarly sources was adopted to ensure there is a high degree of credibility and reliability alike for the information included in the presentation. Even more, the data encompassed in the researches are accurately presented and precise.
  • The list of sources whereby the data has been derived from is included in the bibliography section.
  • Data
  • According to Takamatsu, et al. (1), isolation of pure natural products from cyanobacteria, marine sponges and algae performed at the University of Mississippi successfully led to the identification of valuable anti-oxidants in the components found.
  • As per Kinnel, et al. (2) the use of single-filament MALDI analysis – if used appropriately can enhance drugs identification. That is manifested by the successful completion of Cryptomaldamide – an element that may be used to facilitate biosynthesis in the body – using bioinformatics analysis.
  • Carlos (3) reports that there are more than six basic types of therapeutic elements which are already derived from marine natural products. More so, there are 23 marine products which are under scientific review for drugs development.
  • Leahy (490) further discusses the usage of a phylogeny-based classification in the identification of marine products. For instance, the mechanism has already been used to identify and classify the genus Symploca
  • The journal article explains the importance of technological advances such as Mass Spectrometry and HPLC-MS, especially toward drugs identification and categorization.
  1. Discussion
  • For the ultimate medicinal benefits attached to the natural marine products to be attained there is a need for extensive research. That require advances to happen regarding identification, isolation, and categorization of the compounds or constituents from the marine products.
  • The determination by scientists and drug research groups have been fostered by the rapid finessing of technology.
  • The developments are evident and the discoveries done in the drugs industry highlights the benefits which can be derived from the marine natural products.
  1. Conclusion
  • Researchers have made remarkable development in the field of medicine thanks to marine natural products usability as drugs.
  • There are many drugs which are already in the market and many others which are on the clinical pipeline. To a great extent, the technological developments in the world of science and particularly in the chemistry of products can be credited for that.
  • With more advances expected in the future and the fact that researchers are delving deeper in that direction illustrates the expectations the people can have from marine natural products as they bid to safeguard and improve their health.

Works Cited

Faulkner, D. John. “Highlights of marine natural products chemistry (1972–1999).” Natural product reports 17.1 (2000): 1-6.

Kinnel, R. B., et al. “A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.” Journal of Natural Products, vol. 80, no. 5, 2017, pp. 1514-1521, doi:10.1021/acs.jnatprod.7b00019.

Leahy, J. “Medicinal Chemistry and Lead Optimization of Marine Natural Products.” Marine Biomedicine, 2015, pp. 393-436, doi:10.1201/b19081-17.

Salvador-Reyes, L. A., et al. “Targeted Natural Products Discovery from Marine Cyanobacteria Using Combined Phylogenetic and Mass Spectrometric Evaluation.” Journal of Natural Products, vol. 78, no. 3, 2015, pp. 486-492, doi:10.1021/np500931q.

Takamatsu, S., et al. “Marine Natural Products as Novel Antioxidant Prototypes.” Journal of Natural Products, vol. 66, no. 5, 2003, pp. 605-608, doi:10.1021/np0204038.

Leave a Reply

Your email address will not be published. Required fields are marked *