Ellison-Wright, I., & Bullmore, E. (2010). Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophrenia Research, 117(1), 1.
A 2010 meta-analysis by Ellison-Wright and Bullmore explores existing literature for evidence regarding the potential pathological relationship between schizophrenia and bipolar disorder. The afflictions have been historically perceived as completely separate entities, but recent studies have hinted at an underlying neural overlap between them. Additional support for the association has come from the consistent appearance of both bipolar disorder and schizophrenia in representative family histories. Based on these and other findings, the meta-analysis authors hypothesized that existing MRI-based studies would reveal a significant correlation between brain structure changes found in those with bipolar disorder and those that are apparent in patients with schizophrenia.